Disease-oriented Genome Networks Diseases Due to Environmental Factors Network: Diseases Due to Environmental Factors Project: Bioinformatics Support

Introduction We aim at the development of bioinformatics methods for advancing the understanding of disease processes and the effect of genetic variations on protein function and drug therapies. To this end, application studies on structure and function prediction of medically relevant proteins are being conducted in cooperation with research groups from medical institutes. The bioinformatics service provided consists of various computational analyses of protein sequences of medical interest. Our findings have already led to plausible biological hypotheses that have been and are still of help in prioritizing further experiments. They have advanced the molecular understanding of impaired cellular mechanisms involved with specific diseases. In the following, we detail some of our bioinformatics studies.